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09/28/2026

NGF isn’t just a pain molecule.

A new paper proposes a biologically plausible mechanism for how blocking NGF with Librela could contribute to some of the musculoskeletal, neurologic, and urinary adverse events being reported.

Does it prove causation? No. But it raises questions that deserve further research.

Study: Federico G, Ilardi A, Elia V, Chieffi S. A neurotrophic withdrawal hypothesis for multisystem adverse events associated with anti-NGF therapy for canine osteoarthritis pain. Front Vet Sci. 2026;13:1776920.

09/22/2026

BPC-157 promotes angiogenesis. But does that automatically mean it feeds cancer?

In melanoma cells, BPC-157 reduced VEGF-driven signaling and cancer-cell proliferation.

And in mice with established C26 colon cancer, BPC-157 did not increase tumor growth. Tumor volume was actually numerically lower, although the difference was not statistically significant.

This alone does not prove BPC-157 is safe in cancer. We still need much better long-term research.

Real-world exposure is another piece of the puzzle. BPC-157 has been used for well over a decade, and while we do not know the exact number of users, exposure may now be in the hundreds of thousands worldwide. Despite that growing use, no clear cancer signal has emerged showing increased tumor development or accelerated tumor growth.

That does not prove the risk is zero, but it is another reassuring piece of evidence.

Right now, the concern is biologically plausible while the evidence that BPC-157 actually causes or accelerates cancer simply isn’t there.

Studies:

Radeljak S, Seiwerth S, Sikiric P. BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line. Melanoma Research. 2004;14(4):A14-A15.

Kang EA, Han YM, An JM, et al. BPC157 as Potential Agent Rescuing from Cancer Cachexia. Current Pharmaceutical Design. 2018;24(18):1947-1956.

09/20/2026

Angiogenesis sounds scary when you only hear it discussed in the context of cancer.

But angiogenesis is also a normal part of healing, tissue repair, and adaptation throughout the body.

The real question is not whether something promotes angiogenesis. The better question is whether the research shows an actual increase in cancer risk.

That’s what I’m covering next.

09/19/2026

Peptides are more than just short chains of amino acids.

Many act as signaling molecules, delivering specific biological instructions that can influence inflammation, healing, metabolism, immune function, and more.

That’s what makes peptide science so fascinating.

They’re not magic. They’re biological signals that sometimes produce some pretty remarkable effects.

09/15/2026

Someone commented, “This guy is AI generated, right?” So apparently I now have to prove I exist. And the disturbing part is…I have no idea how to do that on the internet anymore.

09/15/2026

SS-31 may be one of the more interesting peptides to watch in veterinary medicine.

Unlike many peptides being discussed for dogs, SS-31 already has published canine research, including heart failure and mitochondrial studies, plus long-term safety data in Beagles.

And there’s now an FDA-approved human drug made from SS-31.

That doesn’t make it approved for dogs, and many of its potential veterinary applications remain unanswered questions.

But the research is definitely worth paying attention to.

09/08/2026

We have a safety study of BPC-157 in dogs, but safety is only one part of the picture.

A pharmacokinetics study helps answer a completely different question:

What does the dog’s body actually DO with BPC-157?

How quickly is it absorbed?
How much reaches circulation?
How long does the intact peptide remain in the bloodstream?
How is it metabolized and eliminated?

In beagle dogs, BPC-157 was absorbed rapidly after intramuscular injection, reaching peak blood concentrations within minutes.

The intact peptide also had a very short plasma half-life.

However, a short plasma half-life does NOT automatically mean a short biological effect.

Pharmacokinetics tells us how long the intact compound is measurable in circulation. It does not, by itself, tell us how long the downstream biological effects continue.

And while this study gives us some extremely useful information, we still have major gaps, especially for routes like subcutaneous and oral administration.

This is exactly why veterinary specific research matters.

We should not have to rely entirely on extrapolating from humans when we can actually study what happens in dogs.

Study:

He L, Feng D, Guo H, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Front Pharmacol. 2022;13:1026182.

09/08/2026

Processing matters.

A new 2026 study took essentially the same raw ingredient mixture, processed it five different ways, and fed each diet to the same group of dogs.

The results showed measurable differences in nutrient digestibility, f***l metabolites, and specific bacterial populations depending on how the food was processed.

HPP raw had the highest protein digestibility at 94.9%, with steamed food performing extremely well too. The high-heat retorted food had the lowest protein digestibility and produced higher levels of several protein-fermentation byproducts in the colon.

Maybe we need to stop looking only at the ingredient list and start asking instead -

What did we do to those ingredients before they got into the bowl?

Study: Geary EL, et al. Apparent total tract nutrient digestibility of frozen raw, freeze-dried raw, mildly cooked, and retorted dog foods and their effects on f***l characteristics, metabolites, and microbiota of healthy adult dogs. Journal of Animal Science. 2026.

09/02/2026

“BAC water is toxic to dogs.”

Really? Let’s look at that.

Bacteriostatic water, or BAC water, contains 0.9% benzyl alcohol as a preservative so a vial can be accessed multiple times.

Interesting, because benzyl alcohol is already used in veterinary injectables for dogs, including Adequan, acepromazine, certain maropitant products, and multidose propofol.

So apparently benzyl alcohol isn’t magically toxic just because it’s in BAC water.

Toxicity depends on dose, concentration, route, and total exposure.

Context matters.

Dose matters.

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