10/18/2025
This is so true and why we work to avoid this!
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Degenerative Myelopathy (DM) is a progressive spinal cord disease that affects the nerves controlling the hind legs. It is most common in breeds like Corgis, Dachshunds, Boxers, and German Shepherds.
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DM causes gradual loss of nerve function in the spinal cord. Dogs begin to drag their feet or wobble in the hind end, and the weakness slowly progresses to paralysis.
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DM is linked to a mutation in the SOD1 gene.
- Dogs with two copies (A/A) of the mutation are at risk and can develop DM.
- Dogs with one copy (A/N) are carriers. They typically do not develop the disease but can pass the gene to their offspring.
- Dogs with no copies (N/N) are clear and cannot develop or pass on the mutation.
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- Breeding an A/A dog is not recommended.
- Breeding an A/N (carrier) dog to an N/N (clear) dog is acceptable, as none of the puppies will be at risk for developing DM, though some may be carriers.
- Breeding two carriers (A/N x A/N) can produce at-risk puppies, so this pairing should be avoided.
Genetic testing through a cheek swab is simple and helps guide breeding decisions, protecting future generations from this debilitating condition.
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