05/13/2026
This brand new peer-reviewed clinical review highlights emerging safety concerns around anti nerve growth factor arthritis injections like Librela and Solensia. Based on post marketing reports and clinical observations, some dogs developed unusually rapid joint deterioration after treatment, including faster than normal arthritis progression, joint instability, and even structural collapse. In certain cases, these changes appeared after just one or two injections, while others developed more gradually over time. What makes these findings concerning is that they do not resemble typical arthritis, with veterinarians reporting abnormal bone formation, bone erosion, and widespread joint damage, sometimes affecting joints that were not previously identified as diseased. The review suggests a possible biological explanation, noting that nerve growth factor plays a role not only in pain signaling but also in maintaining joint health, meaning blocking it could interfere with the joint’s ability to adapt or repair. While these observations do not prove causation, they raise important questions and highlight the need for careful monitoring and further research.
