09/15/2026
Cushings affects many regions of the horse’s body including the reproductive tract.
New CSU Equine Sciences research!
How might PPID (formerly known as equine Cushing’s disease) affect reproductive health in mares?
A new study from CSU researchers found that inflammation associated with PPID doesn’t appear to be limited to the bloodstream - it extends into the reproductive tract.
Mares with PPID had increased inflammatory signaling in the uterus AND follicle, alongside more immune cells within uterine tissue. Importantly, several measures of uterine inflammation were associated with circulating ACTH concentrations.
Why does this matter? Chronic inflammation in the reproductive tract could help explain some of the reproductive challenges observed in older mares with PPID, although additional studies are needed to determine how these changes directly affect fertility.
A special congratulations to co-first authors Jocelyn Howard and Isabella Hamner, CSU undergraduate researchers who helped lead this work! This project brought together researchers from CSU Department of Animal Sciences, and CSU College of Veterinary Medicine and Biomedical Sciences.
Another great example of CSU students contributing directly to research that advances our understanding of equine reproductive health and aging.
📸: Erica Jacquay
Link to paper: https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1758501/full