09/15/2026
AVMA News
In the three months since New World screwworm (NWS) was detected in the U.S., dozens of cases have been detected in cattle, sheep, goats, and a handful of dogs, mostly in Texas. The U.S. Department of Agriculture is spending more than $1 billion to fight the deadly parasite’s reappearance. AVMA News spoke with experts and reviewed historical documents to better understand what it took to eradicate screwworm the first time from the U.S., what efforts are happening now to detect and control its spread, and how long it will take to get NWS out of the country. This is the first article in our three-part series.
A historical perspective on New World screwworm
Screwworm's return to the U.S. echoes a battle fought—and won—decades ago
By Malinda Larkin
Published on September 08, 2026
Updated on September 11, 2026
When asked how many cases of New World screwworm (NWS) in the U.S. would be acceptable, Dr. Pancho Hubert doesn't mince words: "I think one case is bad."
The Texas VMA president remembers the devastation caused by NWS incursions while growing up in Texas in the 1960s and 1970s.
In 1962, the U.S. reported 51,592 NWS cases, 96% of which were in Texas, according to the U.S. Department of Agriculture's (USDA's) National Agriculture Library (NAL). By 1972, there were more than 95,000 reported NWS cases—90,980 of which were in Texas.
An undated photo of a Texas cattleman roping a calf to be inspected for New World screwworm (NWS) (Photos courtesy of the U.S. Department of Agriculture National Agricultural Library’s Special Collections)
An undated photo of a Texas cattleman roping a calf to be inspected for New World screwworm (NWS) (Photos courtesy of the U.S. Department of Agriculture National Agricultural Library’s Special Collections)
"We were treating a lot of screwworm cases. It was mostly cattle. It really decimated livestock and wildlife," Dr. Hubert said. "There was a lot of collateral damage with an infestation of that magnitude."
AVMA News reviewed historical documents from the NAL’s "STOP Screwworms: Selections from the Screwworm Eradication Collection" and elsewhere to get a larger perspective on how the deadly parasite first emerged as a major threat in the U.S. and how it was successfully eradicated, later providing a blueprint for today's efforts against NWS.
Early treatment options
Screwworm has been present in the western U.S. at least since 1825, according to a 2006 JAVMA article by James L. Alexander, PhD, of the Texas Department of State Health Services.
However, it wasn’t until 1933 that the pest was first documented as a significant problem in the Southeast, following shipments of infested animals from the Southwest.
"The southern portion of Florida is at a latitude that enabled screwworm populations to over-winter," Dr. Alexander wrote. "Prior to the movement of affected livestock, the insect had not been able to migrate eastward far enough to establish over-wintering populations."
In response to the rapidly expanding NWS affected areas, the USDA and southeastern states created the Screwworm Educational Program in 1935 to teach livestock producers how to prevent infestations, according to the USDA's "NWS Historical Economic Impact" document. They were encouraged to calf, brand, and dehorn outside of fly season and avoid wounds when possible.
Initially, the only two effective wound treatments were benzol, to kill the worms, and pine tar oil, to repel flies and aid in healing the wound. These required daily application and confinement of the wounded animal.
Looking for more effective treatments, one USDA entomologist, Edward F. Knipling, PhD, studied various larvicides. By 1941, he and other investigators had developed a targeted NWS insecticide they named Smear 62.
"It was a thin paste formed from a combination of diphenylamine, benzol, turkey red oil, and lampblack. Although this worked better than the previous combination, it still did not kill the fly. A full-scale eradication of the screwworm was needed," according to NAL's "Southeastern United States Collection: Screwworm Eradication Program Records."
Sterile insect technique
In 1933, another USDA entomologist, Emory C. Cushing, PhD, and Walter S. Patton, PhD, a scientist at the University of Liverpool in England, published their discovery that the New World screwworm is a distinct species from the common blowfly. One key difference being that the NWS feeds on living, not dead, tissue.
Edward F. Knipling, PhD (center), conferring with his research team on Sanibel Island, Florida
Edward F. Knipling, PhD (center), conferring with his research team on Sanibel Island, Florida
"Cushing and Patton's discovery in that the screwworm was a different species ignited USDA research on treatment and control. One dilemma facing scientists was that live animals were the only way to produce screwworms for experiments, an inhumane and costly practice," according to the NAL's screwworm documents. "Entomologist Raymond C. Bushland developed an artificial screwworm-rearing medium consisting of ground meat, beef blood, water, and a small amount of formaldehyde. This solution allowed production of a large number of screwworms at minimum cost."
Also around this time, Dr. Knipling had theorized that the screwworm population could be eradicated by inundating the wild population with sterile males, known as the sterile insect technique (SIT). But the question of how to sterilize mass quantities of screwworm flies remained. Then came World War II, effectively halting NWS research until the late 1940s.
In 1946, geneticist Hermann Joseph Muller, PhD, won the Nobel Prize for his discovery that X-ray irradiation creates genetic mutations. It wasn't until 1950, though, when Dr. Muller published an article investigating the sterilization of fruit flies by radiation that USDA investigators realized they had found their answer. Dr. Knipling wrote to Dr. Muller, who encouraged the USDA researcher and his colleagues to try the technique with screwworms.
"Following Knipling's correspondence with Muller concerning the use of radiation to sterilize screwworms in large numbers, Bushland put the idea to the test. Using x-ray equipment from a nearby Army hospital, he and D.E. Hopkins, both in Kerrville, Texas, exposed screwworm flies to radiation, discovering that the flies could be sterilized at certain doses without other serious damage," according to the collection.
Experiments in the early 1950s confirmed the success of the SIT, and the first eradication program using the SIT technology started in 1957 in the southeast. The program lasted nearly two years and cost the federal government and state of Florida $10 million, according to NAL documents. The success of that eradication program led to one for the Southwest in 1962, which lasted four years and cost $32 million.
"Once the United States was free of self-sustaining screwworm populations, a barrier zone was established between Mexico and the United States by releasing sterile male flies in northern Mexico, primarily in the border areas. Releasing the flies deterred the buildup of the natural screwworm population along the Mexico and United States border," NAL documents state.
Maintaining a barrier
Even though the U.S. was declared officially free of indigenous screwworms in 1966, that wasn't the end of it. The NWS barrier zone was large and difficult to maintain.
A map of NWS cases in 1972 in the U.S.
A map of NWS cases in 1972 in the U.S.
Sterile fly production at the Mission, Texas, facility amounted to nearly 200 million flies weekly from 1972-75. In 1975 and 1976, production of sterile flies was reduced to 165 million weekly to save money, and reported cases increased significantly. In addition, from 1971-76, winters were gentle and summers mild in the southwest U.S and northern Mexico, with above normal precipitation, according to records from the time.
"Probably because of the favourable weather, the Gulf Coast ear tick, Amblyomma maculatum, began to increase and spread, infesting large areas in Texas in 1972. Ticks created wounds for screwworms in record numbers from late July to the end of October each year from 1972 to 1976. These additional wounds for screwworm oviposition contributed to additional loss of effectiveness in screwworm control," according to the report, "Screwworm control and eradication in the southern United States of America." "Interest in the development of new and improved screwworm control methods resulted, for example, in the control of the Gulf Coast ear tick by insecticide-impregnated plastic ear tags for cattle."
The last natural incursion of screwworm into the continental United States was from Mexico, which occurred in August 1982 in Starr County, Texas. For more than three decades, only 27 NWS cases had been detected in the U.S., including Puerto Rico, USDA information states.
Then in 2016, an outbreak occurred in the Florida Keys, Florida. In total, there were 145 cases: 128 presumptive cases and 17 confirmed cases of NWS, with the majority (135) of those observed in Key deer, according to an APHIS report.
Otherwise, the SIT had effectively eradicated NWS out of North America and Central America all the way south to the Darien Gap, at the southern end of Panama. The Panama-United States Commission for the Eradication and Prevention of Screwworm has been producing sterile flies since the '90s to maintain this barrier. But in 2023, health authorities noticed incursions of NWS north of the area where the SIT flies were distributed.
By November 2024, a confirmed NWS case in a cow in the southern Mexican state of Chiapas prompted the USDA to ramp up NWS mitigation measures along the U.S. southern border.
Nearly two years later, on June 3, NWS larvae were confirmed in the umbilicus of a 3-week-old calf in Zavala County, Texas, about 45 miles east of the U.S.-Mexico border and 100 miles southwest of San Antonio.
Of the 476 total larval cases submitted to USDA's National Veterinary Services Laboratories since then, 49 have been positive NWS cases and only two of those are active currently.
A USDA Animal and Plant Health Inspection Service chart and map showing progress against NWS in the mid-20th century. In 1941, producer losses were estimated at $5-$10 million annually, nationwide, according to the report. By 1960, estimated livestock losses due to screwworm in the southwest were placed at more than $100 million annually.
A USDA APHIS chart and map showing progress against NWS in the mid-20th century. In 1941, producer losses were estimated at $5-$10 million annually, nationwide, according to the report. By 1960, estimated livestock losses due to screwworm in the southwest were placed at more than $100 million annually.
Dr. Hubert, who practices in Corpus Christi, Texas, is not in the areas directly affected, though there are some cases west of him. He says that, while a ranch's labor force may not be as numerous as it was in the 1960s and 1970s, he’s convinced the U.S. can once again be successful against NWS thanks to today’s technology and a playbook based on what worked in previous response efforts.
"If you compare back in the 70s to today, the difference is astounding. You can see large differences in the total cases of screwworm cases. But it does accentuate the importance of constant vigilance against this scourge," Dr. Hubert said. "Our goal is to get NWS out of Texas and to beat it back to Panama. That is the ultimate goal. It will take everyone’s efforts to accomplish this, including the state and federal government, veterinarians and animal health professionals and the public—in a coordinated and collaborative effort to get this scourge out of Texas."
The AVMA has created a New World screwworm (NWS) page that includes the following resources and more:
Companion animal guidance
A list of all drugs approved for use to combat NWS in animals
Travel to/from Mexico
Livestock/Equid clinical guidance
Client-facing poster: What to look for
Veterinary quick reference
Screwworm guidance for animal shelters