09/11/2026
Legend vs. Adequan š“
When deciding between LegendĀ® and AdequanĀ®, there are several important considerations. Both medications are injectable therapies commonly used to help manage arthritis and joint inflammation in horses. They are not pain medications, but supportive treatments that form part of a comprehensive arthritis management plan.
LegendĀ® contains hyaluronic acid and works primarily by supporting the joint lining and improving the quality of joint fluid. It helps reduce inflammation within the joint environment and is commonly administered once weekly for four weeks as an initial series, after which it may be repeated or continued monthly as needed. LegendĀ® must be administered intravenously. Your veterinarian may also use Legend during joint injections.
AdequanĀ® contains polysulfated glycosaminoglycan (PSGAG) and works by supporting cartilage health and joint fluid production. It is administered as a series of seven intramuscular injections given every four days, and this series is typically repeated every six to twelve months depending on the horseās workload and response.
For older or lightly worked horses, common approaches include using an AdequanĀ® series as a foundation therapy to support cartilage over time, using a four-week LegendĀ® series repeated as needed, or combining AdequanĀ® with intermittent LegendĀ® during periods of increased workload. AdequanĀ® supports deeper joint structures, while LegendĀ® helps optimize joint fluid quality when inflammation is present.
For performance horses, AdequanĀ® is often used as part of long-term joint care, typically at the start of the season and repeated every six months. LegendĀ® is commonly added as a four-week series when training intensity increases or prior to competition blocks to support the joint environment during higher athletic demand.
It is important to note that these medications do not act as immediate pain relievers, do not regenerate severely damaged cartilage, and do not replace appropriate farriery or exercise management. They are best used as part of a multi-modal arthritis plan, which may also include NSAIDs or joint injections when indicated, oral joint supplements, regular balanced farrier care, and controlled exercise programs.