https://www.facebook.com/236882070413255/

Raquel Rodrigues

Como chegar Entre em contato com o negócio

Atendimento clínico de cães |
Psiquiatria canina |
Aromaterapia veterinária |
Reiki |
Acupunt

07/08/2026

🇧🇷 Tem dias que tudo que a gente precisa é de uma mão (ou duas) pra fazer a parte chata do trabalho.
🇨🇦 There are days when all we need is a hand (or two) to do the boring part of the job.

29/07/2026

🇧🇷 Eu amo o meu trabalho!
🇨🇦 I love my job!

04/07/2026

🇧🇷 Obrigada, Benito Soto Blanco por me mostrar como a toxicologia é linda.
🇨🇦 Thank you, Benito Soto Blanco, for showing me how beautiful toxicology is.

24/06/2026

🇧🇷 Saskatoon não é só frio e neve.
🇨🇦 Saskatoon is not just cold and snow.

01/04/2026

Abstract

1. Pharmacokinetic interactions between natural extracts and hepatic cytochrome P450 (CYP) enzymes are a concern in veterinary medicine. Lavender essential oil (LEO), containing linalool (LIN) and linalyl acetate (LINAc), may be coadministered with conventional medicines for treatment of canine anxiety.

2. This study examined the canine metabolism of LIN and LINAc by substrate depletion using pooled dog liver microsomes (pDLMs) and recombinant canine CYP enzymes (rCYPs). Inhibitory effects of LIN, LINAc, and LEO on CYP isoform-selective probe drug reactions were also evaluated.

3. LINAc was hydrolyzed to LIN by a heat-sensitive esterase activity in pDLMs. LIN depletion by pDLMs was NADPH-dependent, saturable with a Michaelis-Menten constant of 52 ± 11 µM, and induced by over 5-fold in liver microsomes from phenobarbital-treated dogs. Recombinant CYP2B11 showed the highest LIN depletion activity, followed by CYP2C21, while other CYPs tested did not show measurable substrate depletion. Inhibition experiments showed that LIN, LINAc, and LEO inhibited CYP2B11-mediated metabolism but not metabolism by CYP2C21, CYP2D15, or CYP3A12. IC50 values for LIN, LINAc, and LEO were 7.1, 2.7, and 2.5 µM for tramadol N-demethylation, and 13.9, 8.0, and 8.6 µM for methadone-N-demethylation, respectively. Interestingly, none of the terpenes were shown to directly inhibit recombinant CYP2B11 activity, suggesting that they exerted indirect inhibition via metabolites generated by other CYPs in pDLMs.

4. These findings highlight CYP2B11 and CYP2C21 as key enzymes in LIN and LINAc metabolism and underscore the potential for herb-drug interactions when treating dogs with lavender essential oil.

12/03/2026

Venha pra Saskatoon.

21/02/2026

Às vezes só precisamos de um espumante pra conseguir digerir alguns conteúdos.

06/02/2026

Segui a dica do e pedi a IA pra criar uma caricatura minha baseada no que ele sabe sobre meu trabalho.
Não poderia ter gerado uma imagem melhor!
(E ainda me colocou usando uma camisa do Galo!)
I followed 's tip and asked the AI to create a caricature of me based on what it knows about my work.
It couldn't have generated a better image!

(And it even put me wearing an Atlético Mineiro shirt!)

05/01/2026

Seja feita a Vossa vontade...
Thy will be done.

25/11/2025

Mais uma discussão linda com a equipe do ! Dessa vez sobre uma das meninas dos meus olhos: dor e analgesia!

Endereço

Belo Horizonte, MG

Site

facebook.com

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