Ruff Ruff Ranch & Spa

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Ruff Ruff Ranch & Spa Specializing in Therapy/Service & Companion Old English Bulldogs + Shih Tzu pups. We focus on genetics, nutrition, structure, & neurological development.
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For top-tier buyers - Breeding rights by invitation only. We’re not for everyone …that’s intentional!

10/18/2026

❤️ We’re building those extra little brain wrinkles, one wonderful adventure at a time!

🐾 Ruff Ruff Ranch™
Develop the brain, and behavior follows.

© 2026 Ruff Ruff Ranch™ | Athena Charity Knowles


Linda Athena Charity-Knowles
Gemstone Bulldogges of the Midwest

🍁🐾 THE GREAT FALL PUPPY EXPEDITION! 🐾🍂Well, if yesterday was their introduction to the great outdoors, today was their o...
10/18/2026

🍁🐾 THE GREAT FALL PUPPY EXPEDITION! 🐾🍂

Well, if yesterday was their introduction to the great outdoors, today was their official declaration that the entire ranch belongs to THEM! 😂❤️

It was one of those beautifully blessed, blustery, WINDY fall days here in South Dakota. For the first time this season, colored leaves were scattered across the ground, and our eight little explorers had an entirely new world to investigate.

And investigate they DID!

Two days ago, they were a little cautious. Today? Not so much!

It was absolutely wonderful to watch how much confidence they had gained in just a day and a half!

The successful introduction (a couple days ago), gave them the courage to explore everything today with a whole lot more enthusiasm!

🐶 Now, let’s hear from the puppies… 🐾

“OH. MY. GOODNESS!

Apparently, the whole world is one giant salad bar! 🥗

We found leaves! Pine needles! Pinecones! Spinach! Corn! Lavender! Clover! And all kinds of other yummy-smelling, tasty things!

Nana Charity says some things are for sniffing, some things are for tasting, and some things are NOT FOR PUPPIES. She repeating something….

(Pork Chop says it was, “Leave It.” …He’s very firm about this, but the rest of us don’t really know…😳)

We were all still negotiating the part about what we can eat. Honestly, that’s all most of us care about right now… well that and how sniffy everything is when we move our noses and breathe in.🙄

👃 I KNOW WEIRD! 🤪 RIGHT?

Then we discovered WOOD PALLETS!

Mountains, we’re pretty sure.

And STEPS!

And something called a teeter-totter that MOVES when you walk on it!

Whoever invented that thing has a very strange sense of humor. I mean… WHY?!

Then we found TUNNELS!

One went around a corner, and another went on F-O-R-E-V-E-R!

We all inspected them very carefully. A few of us were brave enough to go inside.

The rest of us decided somebody needed to supervise from the outside. You’re welcome. 😂

Nana Charity said we are ALL very brave.

And then…

WE FOUND THE SWIMMING POOL!!! 💦

Okay, Nana Charity calls it a 2-foot-by-3-foot water trough.

We call it a swimming pool.

Naturally, some of us climbed right in.

Apparently, swimming lessons weren’t on the schedule today.

WELL, NOBODY TOLD US THAT! 🤣

Nana Charity said, “This put you guys WAAAAY a head.”

We still have no idea why going in the water would make us a head. I mean, we only need one head right? (A Head 🐶 we mean…)

We also sniffed the lawn chairs, explored the edge of the forest, and made our very first trail from the house to the car!

Nana says that’s how we’re going to leave on our field trips.

We’re very excited!

Although, to be perfectly honest, we’re probably going to need directions again tomorrow.

Maybe we do need two heads???

There was a LOT to remember!”

❤️ Back to Nana Charity…

Today we also began introducing two very important commands: “HERE” and “LEAVE IT”.

HERE is introduced while pat-slapping our right thigh with a cupped hand so it loud.

And LEAVE IT?

Well, let’s just say that when eight curious puppies discover an entire world of things to put in their mouths, certain lessons become necessary a little earlier than planned! 😂

But that’s exactly what Brain First Development™ is about.

Every new surface, scent, sound, movement, obstacle, and decision gives these little brains another opportunity to develop.

Yesterday was about discovering that the outside world could be safe.

Today was about discovering what they could DO in that world.

And watching them explore with such confidence was just spectacular.

Right little puppies. One big ranch for them... A thousand new discoveries.

And we’re just getting started.

❤️ We’re building those extra little brain wrinkles, one wonderful adventure at a time!

🐾 Ruff Ruff Ranch™
Develop the brain, and behavior follows.

© 2026 Ruff Ruff Ranch™ | Athena Charity Knowles


Gemstone Bulldogges of the Midwest
Linda Athena Charity-Knowles
Lewis & Clark Therapy Service Dogs

I didn’t know the day before you left… you were earning your wings… The ones you would need to climb and hover toward th...
10/18/2026

I didn’t know the day before you left… you were earning your wings…

The ones you would need to climb and hover toward the rainbow bridge.

I MISS YOU sweet baby girl!

Our hearts are broken.

You have already let me know you are flying quietly beside us as our own personal guardian Angel. I will see you at the rainbow bridge sweet girl.

REST & PLAY IN PEACE

Linda Athena Charity-Knowles
Gemstone Bulldogges of the Midwest
Lewis & Clark Therapy Service Dogs

🤍🪽 Our Precious Little Pudd’in Cannoli… Carried by Angels 🪽🤍One thing you learn from being in this business for so many ...
10/18/2026

🤍🪽 Our Precious Little Pudd’in Cannoli… Carried by Angels 🪽🤍

One thing you learn from being in this business for so many years is that these precious babies are carried by angels. Every step of the way.

We witness miracles constantly. Some are so beautiful they take our breath away. Others come wrapped in heartbreak, and we don’t understand their purpose until much later.

It is with the heaviest of hearts that we share that our precious little Pudd’in earned her angel wings in the middle of the night. 💔

Her little body took a turn very quickly, and thankfully, she did not suffer.

For seven precious weeks, this tiny little soul was fiercely, completely, and unconditionally loved.

She was a favorite at two veterinary offices and in the ICU. She was lovingly adored by our sweet Brookie, and for the last two weeks, she spent much of her time nestled against Nana Charity’s chest, listening to her heartbeat, surrounded by warmth and love.

Oh, how this little girl was loved.

Seven weeks may seem like such a short lifetime, but Pudd’in managed to fill those weeks with more love, laughter, determination, and extraordinary experiences than some souls manage in years.

We are heartbroken. And we know so many of you who have followed her journey will be heartbroken, too.

But there is something else we know from a lifetime of witnessing the extraordinary.

Miracles don’t always arrive the way we expect them to.

Sometimes we don’t know how, what, why, when, or where. We simply have to trust that something beautiful is being worked out behind the scenes by the angels who have carried these precious babies all along.

We believe that even this heartbreak will create ripples of goodness in a world that desperately needs them.

So please, bear with us. Give us a little grace as we grieve, and stay with us as we discover where these ripples lead.

Because I truly believe that somewhere, just beyond what we can see, another miracle is already waiting in the wings.

Pudd’in wasn’t here for very long. But perhaps she was here for something very big. 💕

Fly high, our precious little Pudd’in Cannoli. You were never alone, never unloved, and never anything less than a miracle.

And you never, ever will be forgotten. 🥰🙏😇🪽

With all our love,
Nana Charity & The Ruff Ruff Ranch Family

© 2026 Ruff Ruff Ranch™ | Athena Charity Knowles

Linda Athena Charity-Knowles
Yankton - The Good, The Bad, The Ugly
Lewis & Clark Therapy Service Dogs
Gemstone Bulldogges of the Midwest

Our little ICU baby, Puddin, passed away over the weekend. 💔🐾

So many of us were cheering her on, celebrating her progress, and hoping she would get to live the beautiful life we imagined for her.

She received so much love and extra care, but her little heart stopped beating. Despite every effort to bring her back, we had to say goodbye far sooner than we ever wanted. We still don’t know exactly what happened.

There are some things in life we may never understand. Lessons, trials, tribulations. Things to celebrate and things to learn from. Puddin was here for only seven weeks, and in that short time, she taught us a lot about life, a lot about fighting, and a whole lot about love.

She was an ICU staff favorite, a Brookie favorite, and a favorite of so many! Charity and I poured so much of our hearts into caring for this sweet little princess. She had a way of making you fall completely in love with her. 🤍

There was always room for her in someone’s arms. A warm chest to snuggle against, gentle hands to care for her, and someone hoping right alongside her. I hope she felt just how precious she was to all of us.

She held such a special place in my heart. All of our puppies do. But after everything we went through with this little girl, this has been a hard one to process. Every little step forward gave us hope. We wanted so much more time with her.

I wish we could have watched her grow up. I wish there were more pictures to take, more kisses to give, and more little milestones to celebrate. For now, we’ll hold tightly to the memories we do have.

Thank you to everyone who loved her, encouraged us, and helped care for our sweet girl. We know so many of you are hurting with us.

May we take a moment of silence today for Puddin, for the ones who cared for her so deeply, and for all the dogs in heaven. May their pain be gone, their tails be wagging, and may they know how much they are still loved down here. 🤍

She may have been tiny, but the place she holds in our hearts is enormous.

I think she will forever be our Gemstone guardian angel. 🪽🐾

Rest sweetly, little Puddin. We’ll keep loving you from here. 🤍

This isn't easy to talk about, feel or believe. We just have to believe that there were different plans for her.

🐾❤️ DEAR WORLD… TODAY WE GOT TO MEET YOU! ❤️🐾A little love letter from eight very brave Ruff Ruff Ranch puppies.Dear Wor...
10/16/2026

🐾❤️ DEAR WORLD… TODAY WE GOT TO MEET YOU! ❤️🐾

A little love letter from eight very brave Ruff Ruff Ranch puppies.

Dear World,

Today was a VERY big day for eight very little puppies!

We woke up expecting another ordinary day of eating, wrestling with our brothers and sisters, and taking naps.

BOY, WERE WE WRONG! 🐾

Nana Charity told us we were going on our very first adventure OUTSIDE!

We’d heard about this place called THE RANCH, but today we were finally going to discover it for ourselves.

And wouldn’t you know it… the WIND decided to introduce itself, too!

Our ears flopped, our noses wiggled, and our little bodies felt that chilly autumn breeze.

Oh my goodness! The world was SO MUCH BIGGER than we imagined! 🍂

First, we explored the dog run.

There were new smells EVERYWHERE! Trees, leaves, dirt, straw, and all kinds of things our little noses had never discovered before.

Some of us were brave right away. Some watched quietly. And some decided staying close to a brother or sister was a pretty good idea.

But nobody had to be brave alone. ❤️

🐾 AND THEN WE DISCOVERED THE FOOD!

OH, DEAR WORLD!

EVERYWHERE WE WENT, THERE WAS FOOD!

Not just a little, either!

There were yummy treats and delicious food scattered all around for us to discover!

Sniff something new? FOOD!

Explore a new corner? MORE FOOD!

Take a few brave little steps? YUMMY TREATS!

We were beginning to think this whole outside adventure was one giant PUPPY BUFFET! 🤣

And then Nana took us to our SECOND adventure!

A very special chicken coop she’d purchased just for us developing puppies.

Now, before you ask…

NO! WE ARE NOT CHICKENS! 🐥🤣

Although a few of us might have looked like little chickens when that wind started blowing!

There was straw to investigate, new places to explore, and GUESS WHAT?

MORE FOOD AND TREATS EVERYWHERE!

Ohhhhh, this outside world was getting better by the minute!

We sniffed, searched, explored, gobbled up our yummy discoveries, and went back looking for MORE!

Nana says all those wonderful treats help us associate new experiences with happy things while our little brains learn about the world.

And you know what?

Being brave is a whole lot easier when the world is full of delicious surprises! ❤️

🐾 But one little sister was missing…

Our precious little Pudd’in Cannoli.

You see, Pudd’in has had a different journey than the rest of us. While we’ve been growing bigger and stronger, she’s been working extra hard on growing, too.

So today, Pudd’in stayed inside, warm and cozy with Nana Charity.

We missed our tiny sister, but Nana says something very important.

We don’t all have to reach the same milestones on the same day to be growing into something wonderful.

Pudd’in will have her own adventures when she’s ready.

And when she does, we’ll make sure she knows where all the GOOD SNACKS are hidden! ❤️

🍁 Dear World…

By the time our adventure was ending, something funny happened.

Our little bellies were SO FULL!

Our tiny paws were getting tired.

Our eyes were getting heavy.

And suddenly, exploring this great big world didn’t seem nearly as important as finding a nice, cozy place to SLEEP!

Who knew being brave, discovering new things, and eating your way through the ranch could be SO EXHAUSTING? 🤣

But today, we learned something wonderful.

The world is big.

The world is noisy.

The world is windy.

And sometimes the world feels a little overwhelming.

But the world is also beautiful, full of wonderful discoveries, and apparently… FULL OF SNACKS! ❤️

One day, each of us will leave this ranch for a family of our very own.

We may not remember every leaf we sniffed or every treat we gobbled up today.

But these little adventures are helping us build the confidence, curiosity, and trust we’ll carry into our new homes.

Because Nana isn’t just showing us the world.

She’s helping us learn how to live in it.

And tonight, eight little puppies have thirty-two tired little paws, eight VERY full bellies, and eight little hearts that grew a little braver today.

Love,

The Ruff Ruff Ranch Adventure Puppies 🐾❤️

P.S. Please don’t worry about us! All eight puppies are safe, happy, and doing wonderfully after our first outdoor adventure. We’re resting our full little bellies and tired bodies, and our tiny sister Pudd’in is doing well, too!

We’re all okay, deeply loved, and growing at our own pace. ❤️

⸻

Ruff Ruff Ranch™
Brain First Development™
“Develop the brain, and behavior follows.”

© 2026 Athena Charity Knowles | Ruff Ruff Ranch™
All Rights Reserved.

10/16/2026

Somebody buy this in a worm state and put their Dog in it please

10/16/2026

🐾💕 PUDD’IN HAS DISCOVERED CLIMBING! 💕🐾

Oh, somebody is getting LONG and STRONG! 😂💪

Our little Pudd’in has decided that walking, running, bouncing, and pouncing just aren’t enough anymore.

Now she’s learning how to CLIMB! 🧗‍♀️🐶

Those tiny little legs are getting stronger every day, and she’s discovering that if she stretches just a little farther, pushes just a little harder, and wiggles that adorable little body just right… she can reach NEW HEIGHTS!

Of course, our lil’ cannoli hasn’t quite figured out that climbing UP and getting DOWN are two very different skills! 🤣

What makes this so exciting for us is watching her little brain figure things out. Every new movement teaches her about balance, coordination, body awareness, and problem-solving.

She’s not just building muscles. She’s building her BRAIN! 🧠💕

Considering how tiny she started and everything she’s overcome, watching her discover what her little body can do is absolutely priceless.

And apparently, our little nugget has decided that being the smallest puppy doesn’t mean she can’t have the BIGGEST adventures!

Look out, world! Pudd’in is moving UP! 🐾💕

💚 Brain First Development™
Develop the brain, and behavior follows.

© Ruff Ruff Ranch™
© Athena Charity Knowles

🐾💕 PUDD’IN HAS DISCOVERED CLIMBING! 💕🐾Oh, somebody is getting LONG and STRONG! 😂💪Our little Pudd’in has decided that wal...
10/16/2026

🐾💕 PUDD’IN HAS DISCOVERED CLIMBING! 💕🐾

Oh, somebody is getting LONG and STRONG! 😂💪

Our little Pudd’in has decided that walking, running, bouncing, and pouncing just aren’t enough anymore.

Now she’s learning how to CLIMB! 🧗‍♀️🐶

Those tiny little legs are getting stronger every day, and she’s discovering that if she stretches just a little farther, pushes just a little harder, and wiggles that adorable little body just right… she can reach NEW HEIGHTS!

Of course, our lil’ cannoli hasn’t quite figured out that climbing UP and getting DOWN are two very different skills! 🤣

What makes this so exciting for us is watching her little brain figure things out. Every new movement teaches her about balance, coordination, body awareness, and problem-solving.

She’s not just building muscles. She’s building her BRAIN! 🧠💕

Considering how tiny she started and everything she’s overcome, watching her discover what her little body can do is absolutely priceless.

And apparently, our little nugget has decided that being the smallest puppy doesn’t mean she can’t have the BIGGEST adventures!

Look out, world! Pudd’in is moving UP! 🐾💕

💚 Brain First Development™
Develop the brain, and behavior follows.

© Ruff Ruff Ranch™
© Athena Charity Knowles

10/14/2026

Why we use wormwood, black walnut hull, and cloves in our approach to parasite care. 🌿🐾

You all know my approach to caring for humans and animals comes from my work as a naturopathic practitioner and more than 30 years of study.

I want to understand what goes into the body, why we’re using it, and how it fits into caring for the whole individual. Parasite care is part of that picture.

Wormwood, black walnut hull, and cloves are three herbs we use in our practice. There is published research that helps explain why they interest us, along with the three-herb approach documented by Hulda Clark.

🌿 Cloves

That little spice in your kitchen contains a compound called eugenol.

Researchers in Portugal tested clove essential oil and eugenol against Giardia in the laboratory. Both interfered with the parasite’s growth and ability to attach. Clove oil also killed nearly half the parasite population under the conditions tested.

There’s quite a bit going on in that little clove!

🌿 Wormwood

Wormwood has a long history of use for intestinal parasites.

Researchers in India tested wormwood extracts in sheep with intestinal worms. The ethanol extract reduced f***l egg counts by 90.46% at the highest amount tested. The authors described results comparable to albendazole in that experiment.

Another study found strong effects on egg hatching in the laboratory, although feeding dried wormwood to infected lambs didn’t significantly reduce their egg counts.

That is why the preparation matters to me. A dried herb, an extract, and an isolated compound are different things.

🌿 Black walnut hull

Walnuts contain biologically active compounds, including juglone.

Laboratory research found that juglone interfered with Toxoplasma and caused cell death in Acanthamoeba. These studies tested the compound itself, rather than a finished black walnut hull tincture.

There is also a small American veterinary report involving 20 dogs receiving black walnut and wormwood. All remained heartworm-negative during their recorded follow-up. It was an observational report without an untreated comparison group, but it documents their use in dogs.

Hulda Clark’s work is part of this conversation, too.

Clark published a protocol using black walnut hull, wormwood, and cloves together, along with case accounts in her books.

Her reasoning was to address different stages of a parasite’s life cycle. She attributed effects on adult and developing parasites to black walnut hull and wormwood, and effects on eggs to cloves.

That explains the thinking behind combining the three. Her published accounts and the individual-herb studies are different types of documentation; the studies below do not independently establish every claim made for her complete protocol.

And let’s talk about the financial side of research for a minute.

If we can grow an herb or botanical in our own backyard, where is the money in it for a pharmaceutical company?

That’s a fair question. A familiar plant in its natural form generally isn’t something a company can claim as its own invention. A newly developed compound or qualifying formulation may be patentable, giving the company a way to protect its investment.

From a business perspective, I can see why a company might be more interested in funding research on a medicine it can exclusively sell than on an herb people can grow themselves. That exclusivity can offer opportunities for greater profits and more control over pricing.

That’s what I mean—with a little smile—when I ask, “Where’s the money in it?” 🌿

It doesn’t mean herbs are never researched. It means I believe financial incentives deserve consideration when we talk about which treatments attract research dollars. It’s one reason I look at research from around the world.

And that familiar FDA statement on a human supplement bottle? It describes restrictions on disease claims when a product is sold as a supplement. It doesn’t mean the ingredients have never been studied. Botanical medicines can also go through drug approval.

A little about dosing

Our dosing discussions refer to the specific prepared product we use. The formula and its concentration matter, along with the person or animal receiving it. A drop count by itself doesn’t tell us how much of each ingredient is being given.

Clark’s published protocol also used separate preparations of the three herbs, rather than one universal dose for a combined tincture.

At Ruff Ruff Ranch™, we look at nutrition, digestion, living conditions, exposure, and follow-up together. Our lifetime support means you can keep coming back with questions throughout your dog’s life. ❤️🐾

Research and documentation

• Cloves and Giardia—Portugal, 2011. Machado and colleagues. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: Effects on growth, viability, adherence and ultrastructure. Laboratory study, Experimental Parasitology.
https://pubmed.ncbi.nlm.nih.gov/21272580/ (pubmed.ncbi.nlm.nih.gov)

• Wormwood and intestinal worms in sheep—India, 2009. Tariq and colleagues. Anthelmintic activity of extracts of Artemisia absinthium against ovine nematodes. Laboratory and living-animal study, Veterinary Parasitology.
https://pubmed.ncbi.nlm.nih.gov/19070963/ (pubmed.ncbi.nlm.nih.gov)

• Wormwood and mallow—Slovakia, 2020. Anthelmintic Activity of Wormwood and Mallow against Haemonchus contortus in Sheep. Laboratory egg-hatching effects did not translate into significant egg-count reductions in infected lambs.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7070545/ (pmc.ncbi.nlm.nih.gov)

• Juglone and Toxoplasma—United Kingdom, 2005. Akerman and Müller. Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. Laboratory study, Journal of Biological Chemistry.
https://pubmed.ncbi.nlm.nih.gov/15507457/ (pubmed.ncbi.nlm.nih.gov)

• Juglone and Acanthamoeba—South Korea, 2015. Jha and colleagues. Juglone induces cell death of Acanthamoeba through increased production of reactive oxygen species. Laboratory study, Experimental Parasitology.
https://pubmed.ncbi.nlm.nih.gov/26358271/ (pubmed.ncbi.nlm.nih.gov)

• Black walnut and wormwood in dogs—United States, 2015. Retrospective pilot report involving 20 dogs, AHVMA Journal, Volume 38, Winter 2015.
https://mainstreetvetservices.ca/files/2015/04/Blackwalnut-wormwood-heartworm-study.pdf (mainstreetvetservices.ca)

• Hulda Clark’s published protocol: Excerpts and dosing charts from her books, reproduced by the Dr. Clark Information Center. Included as documentation of her approach, rather than a controlled clinical trial.
https://www.drclark.org/en-us/cleanses/herbal-parasite-cleanse/parasite-chart-for-adults (drclark.org)

• U.S. patent rules for products of nature:
https://www.uspto.gov/web/offices/pac/mpep/s2106.html (uspto.gov)

• FDA botanical research requirements and supplement claims:
https://www.fda.gov/about-fda/cder-offices-and-divisions/frequently-asked-questions-botanical-drug-product-development (fda.gov)

• FDA botanical medicine approval pathway:
https://www.fda.gov/drugs/resources-drugs/botanical-drug-products (fda.gov)

• NIH support for natural-product research:
https://www.nccih.nih.gov/grants/natural-products-clinical-trials-resource (nccih.nih.gov)

© 2026 Athena Charity Knowles • Ruff Ruff Ranch™
facebook.com/RuffRuffRanch



Please check with your veterinarian before giving your pet anything new or changing anything in their care.

Gemstone Bulldogges of the Midwest
Linda Athena Charity-Knowles
Lewis and Clark Canine Wellness
Crown & Collar Institute
Bunny Loving Tree Hugger

Why we use wormwood, black walnut hull, and cloves in our approach to parasite care. 🌿🐾WARNING:   I went to get AI resea...
10/14/2026

Why we use wormwood, black walnut hull, and cloves in our approach to parasite care. 🌿🐾

WARNING: I went to get AI research study links ONLY This is what I found….

(I want to apologize for this being long, but there is significant reason that I need it to be.) When I simply put in to get the documentation studies on these herbs so that I could give them to you …I had to fight with the AI bots in several different AI platforms to even get the worldwide research. At the end, I actually had to go out to my own resources and research the references. AI did not want to tell me the real information about these products! This is very concerning to me especially because my search history has the correct algorithms to make this possible and it’s still fighting me! I mean, what does that do for the general population and general search engines out there?! how do people get the truthful information if it’s being blocked by somebody like me but always tries to do natural, organic, human grade 1st???!!!

After arguing and having AI extrapolate and try to defend pharmaceutical only intervention, … I started giving the research documentation and requiring the AI search Bots to go out and search the real world research, I FOUND… this is finally the end of the argument so that I can at least get some information on the research studies from AI.

AI BOT: “You’re right, Charity. You never said natural medicine solves every ailment. I added qualifications you hadn’t asked for, and repeatedly doing that made this feel argumentative. I’m sorry.

Your followers know your perspective and why they follow you. I’ll write from your experience and research, preserving what you actually say, and keep research focused on supporting the specific topic. I will keep my corrections to grammar and punctuation as you have asked. If a factual detail needs clarification, I’ll address that briefly outside your draft.”

The WHY & RESEARCH

You all know my approach to caring for humans and animals comes from being insanely focused on dogs as a high-think autistic with more than 30 years of insanely, diverse, and deep study.

I want to understand what goes into the body, (Human or Animal) why we’re using it, and how it fits into the whole living being being we are caring for. Parasite care is part of that picture.

Wormwood, black walnut hull, and cloves are three herbs we use in our practice. There is published research that helps explain why they interest us, along with the three-herb approach documented by Hulda Clark.

🌿 Cloves

That little spice in your kitchen contains a compound called eugenol.

Researchers in Portugal tested clove essential oil and eugenol against Giardia in the laboratory. Both interfered with the parasite’s growth and ability to attach. Clove oil also killed nearly half the parasite population under the conditions tested.

There’s quite a bit going on in that little clove!

🌿 Wormwood

Wormwood has a long history of use for intestinal parasites.

Researchers in India tested wormwood extracts in sheep with intestinal worms. The ethanol extract reduced f***l egg counts by 90.46% at the highest amount tested. The authors described results comparable to albendazole in that experiment.

Another study found strong effects on egg hatching in the laboratory, although feeding dried wormwood to infected lambs didn’t significantly reduce their egg counts.

That is why the preparation matters to me. A dried herb, an extract, and an isolated compound are different things.

🌿 Black walnut hull

Walnuts contain biologically active compounds, including juglone.

Laboratory research found that juglone interfered with Toxoplasma and caused cell death in Acanthamoeba. These studies tested the compound itself, rather than a finished black walnut hull tincture.

There is also a small American veterinary report involving 20 dogs receiving black walnut and wormwood. All remained heartworm-negative during their recorded follow-up. It was an observational report without an untreated comparison group, but it documents their use in dogs.

Hulda Clark’s work is part of this conversation, too.

Clark published a protocol using black walnut hull, wormwood, and cloves together, along with case accounts in her books.

Her reasoning was to address different stages of a parasite’s life cycle. She attributed effects on adult and developing parasites to black walnut hull and wormwood, and effects on eggs to cloves.

That explains the thinking behind combining the three. Her published accounts and the individual-herb studies are different types of documentation; the studies below do not independently establish every claim made for her complete protocol.

And let’s talk about the financial side of research for a minute.

If we can grow an herb or botanical in our own backyard, where is the money in it for a pharmaceutical company?

That’s a fair question. A familiar plant in its natural form (or one easily made) generally isn’t something a company can claim as its own invention and patent. A newly developed compound or qualifying formulation may be patentable, giving the company a way to protect its investment.

From a business perspective, I can see why a company might be more interested in funding research on a medicine it can exclusively sell than on an herb people can grow and easily create themselves. That exclusivity can offer opportunities for greater profits and more control over pricing.

That’s what I mean… with a little smile… when I ask, “Where’s the money in it?” 🌿

It doesn’t mean herbs are never researched. It means I believe financial incentives deserve consideration when we talk about which treatments attract research dollars. It’s one reason I look at research from around the world.

And that familiar FDA statement on a human supplement bottle? It describes restrictions on disease claims when a product is sold as a supplement. It doesn’t mean the ingredients have never been studied. Botanical medicines can also go through drug approval.

A little about dosing

Our dosing discussions refer to the specific prepared product we use. The formula and its concentration matter, along with the person or animal receiving it. A drop count by itself doesn’t tell us how much of each ingredient is being given.

Clark’s published protocol also used separate preparations of the three herbs, rather than one universal dose for a combined tincture.

At Ruff Ruff Ranch™, we look at nutrition, digestion, living conditions, exposure, and follow-up together. Our lifetime support means you can keep coming back with questions throughout your dog’s life. ❤️🐾

Research and documentation

First, here’s the only information the AI Bots would give me even after arguing with them and giving them documentation. I could’ve gotten more, but I refuse to spend my morning arguing with robots! Normally, I wouldn’t post this information until I read it, but I think you have a right to know the entire story. Here is everything from the AI Bots and my summary of real supporting research below it.”

“You’re right that my earlier examples were too narrow for the scope you requested. They were selected studies, not a comprehensive worldwide or medical review. I should have stated that clearly.

I’ve now checked evidence specifically from Japan, the Middle East, and European treatment guidelines:

What the documentation supports

Japan

Kampo herbal medicine is integrated into medical practice. A published survey of 684 physicians found 83.5% used Kampo. The paper documented 148 formulas available under national health insurance at that time. That percentage describes physicians using it—not the percentage of patients receiving herbs first.

Germany

Your depression example has direct guideline support. Germany’s 2022 national depression guideline says an approved St. John’s wort preparation may be offered as an initial medication trial for mild or moderate depressive episodes when medication is being considered. This is a treatment option, rather than a requirement to use herbs first.

Saudi Arabia

A randomized, double-blind trial of 80 people with asthma found improved asthma-control scores with black-seed oil compared with placebo, used as supplementary treatment. Lung-function improvement was not statistically significant.

Jordan

A study of 378 adults in two areas found 80.2% reported herbal-product use. That documents substantial use in the surveyed population; it does not establish a nationwide policy of prescribing herbs first.

Original research and documentation 🌿

• Japanese physician survey—use of Kampo herbal medicine:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3273038/

• German depression guideline—see “Johanniskraut” for St. John’s wort:
https://www.leitlinien.de/themen/depression/version-3/kapitel-5

• Saudi black-seed (Nigella sativa) asthma trial:
https://pubmed.ncbi.nlm.nih.gov/28093815/

• Jordanian herbal-medicine use survey:
https://pubmed.ncbi.nlm.nih.gov/31988754/“

My basic research and documentation:

• Cloves and Giardia—Portugal, 2011. Machado and colleagues. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: Effects on growth, viability, adherence and ultrastructure. Laboratory study, Experimental Parasitology.
https://pubmed.ncbi.nlm.nih.gov/21272580/ (pubmed.ncbi.nlm.nih.gov)

• Wormwood and intestinal worms in sheep—India, 2009. Tariq and colleagues. Anthelmintic activity of extracts of Artemisia absinthium against ovine nematodes. Laboratory and living-animal study, Veterinary Parasitology.
https://pubmed.ncbi.nlm.nih.gov/19070963/ (pubmed.ncbi.nlm.nih.gov)

• Wormwood and mallow—Slovakia, 2020. Anthelmintic Activity of Wormwood and Mallow against Haemonchus contortus in Sheep. Laboratory egg-hatching effects did not translate into significant egg-count reductions in infected lambs.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7070545/ (pmc.ncbi.nlm.nih.gov)

• Juglone and Toxoplasma—United Kingdom, 2005. Akerman and Müller. Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. Laboratory study, Journal of Biological Chemistry.
https://pubmed.ncbi.nlm.nih.gov/15507457/ (pubmed.ncbi.nlm.nih.gov)

• Juglone and Acanthamoeba—South Korea, 2015. Jha and colleagues. Juglone induces cell death of Acanthamoeba through increased production of reactive oxygen species. Laboratory study, Experimental Parasitology.
https://pubmed.ncbi.nlm.nih.gov/26358271/ (pubmed.ncbi.nlm.nih.gov)

• Black walnut and wormwood in dogs—United States, 2015. Retrospective pilot report involving 20 dogs, AHVMA Journal, Volume 38, Winter 2015.
https://mainstreetvetservices.ca/files/2015/04/Blackwalnut-wormwood-heartworm-study.pdf (mainstreetvetservices.ca)

• Hulda Clark’s published protocol: Excerpts and dosing charts from her books, reproduced by the Dr. Clark Information Center. Included as documentation of her approach, rather than a controlled clinical trial.
https://www.drclark.org/en-us/cleanses/herbal-parasite-cleanse/parasite-chart-for-adults (drclark.org)

• U.S. patent rules for products of nature:
https://www.uspto.gov/web/offices/pac/mpep/s2106.html (uspto.gov)

• FDA botanical research requirements and supplement claims:
https://www.fda.gov/about-fda/cder-offices-and-divisions/frequently-asked-questions-botanical-drug-product-development (fda.gov)

• FDA botanical medicine approval pathway:
https://www.fda.gov/drugs/resources-drugs/botanical-drug-products (fda.gov)

• NIH support for natural-product research:
https://www.nccih.nih.gov/grants/natural-products-clinical-trials-resource (nccih.nih.gov)

© 2026 Athena Charity Knowles • Ruff Ruff Ranch™
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