DogGenes

DogGenes DogGenes brings the expertise of Clinical Genetic Counseling to dogs and those who love them.

03/23/2025

Helping you understand genetics- Quiz question for the day: breed a tawny/fawn/shaded sable Briard to a yellow lab. What color will the puppies be and why? Answer to come!

Www.undiagnosedfilm.com what a wonderful film!  Watch and support!!!
09/26/2024

Www.undiagnosedfilm.com what a wonderful film! Watch and support!!!

UNDIAGNOSED is currently running an Impact Campaign and meeting with distributors about a public release for the documentary. Once a deal has been negotiated, UNDIAGNOSED will be available on a streaming platform, tv network, and/or other educational platforms. Sign up for our email list to get the....

08/21/2024

We are beyond thrilled to announce that our sweet Wrigley, the golden retriever puppy with a cleft palate, has found his forever home! 🐾💛 We received so many wonderful applications, making this an incredibly tough decision, but we know Wrigley is going to the perfect family. We are so grateful for everyone who showed interest in this special boy and for supporting his journey. It’s been such a joy to watch him grow, and we can’t wait to see him thrive in his new home! Thank you to everyone who has been part of his story. ❤️"

Wonderful work by Fuzzy Texan Animal Rescue !Note my comments also pasted here below. Telling the difference between con...
08/21/2024

Wonderful work by Fuzzy Texan Animal Rescue !

Note my comments also pasted here below. Telling the difference between congenital, genetic, “environmentally caused disease can be difficult. I will be interested to see if these puppies actually tested positive the MCHR2 genetic variant. I will hope not and that their issues were due to their many parasites and can be cleared up with proper treatment.

Wow! Thank you to all of your dedication and hard work.

Regarding 1. and 2. Not all dogs with megaesophagus can be detected with genetic testing.

1. I wanted to clarify-did you submit genetic testing on any of the puppies or did they test positive for megaesophagus via diagnostic testing?

I would love to share the genetic testing results if they have been done. If they have not been-I would love to assist as this would be valuable information if positive

https://news.clemson.edu/researchers-discover-genetic-cause-of-sometimes-deadly-esophageal-disorder-in-dogs/ #:~:text=The%20MCHR2%20variant%2C%20along%20with,(s)%20their%20dog%20inherited.

2. If they are diagnosed with megaesophagus via clinical testing only-I would like to share a story on the importance of worming. I took a litter of Briard puppies to A&M for evaluation for megaesophagus/developmental ring anomaly. This was an early litter and I was trying to raise my puppies as “naturally” as possible so did not do routine “puppy worming” because I was not convinced they needed this.

Ultimately-my puppies symptoms were due to hook or round works and cleared up completely once properly wormed. I will hope that the surviving puppies turn out to have “megaesophagus” due to worms and there health issues will resolve once properly treated for parasites.

You sound like a wonderful group. Thank you again for all of your hard work and dedication to dogs in need.

**Update on the Labs**

As many of you know, we recently took in six Labrador puppies, approximately eight weeks old, surrendered by a breeder. Unfortunately, the information we received about their health was not entirely accurate, leading to a series of unexpected challenges. We spent several thousand dollars on testing—PCR tests, scopes, x-rays, barium swallow tests—trying to figure out what was going on. The results? Positive for mycoplasma, coccidia, and roundworms. Thankfully, they were negative for Parvo, but despite anti-nausea medications, the pups continued to struggle. The most significant finding was that all six puppies tested positive for megaesophagus, a condition that is extremely difficult to manage and places a heavy burden on our foster volunteers.

We don’t mind stepping in to help a breeder, especially when the alternative might be euthanasia or a trip to the shelter. In fact, we’ve built strong relationships with some breeders who genuinely want to learn from the education we provide. However, this situation felt like a gut punch—not just to our bank account, but to the volunteers who poured their hearts into caring for these pups.

**A Public Service Announcement to Breeders:**

1. **Genetic Testing**: If you’re running a breeding program, please ensure both the male and female are genetically tested. This can prevent the passing on of severe conditions like megaesophagus.

2. **Deworming**: Every animal in your care should be dewormed, starting puppies on a strict schedule at two weeks of age.

3. **Vaccinations**: Educate yourself on vaccines—what to give, when to start, and how to prevent diseases like Parvo or kennel cough. No puppy without three rounds of vaccines should ever touch the ground.

4. **Kennel Hygiene**: Properly treat conditions like coccidia and Giardia, and maintain a clean kennel to prevent the spread of these parasites.

If these precautions are taken, many health issues could be avoided, along with the resulting costly medical bills and heartache.

Finally, if you’re going to surrender an animal to a rescue, be 100% honest about its health upfront. Withholding information leads to unnecessary medical expenses that could have been used to help other animals in need. Being smart and honest is all we ask.

We wholeheartedly thank every single one of you that volunteered to help these babies. Sadly, we have lost three of them and our hearts go out to those families who became so involved and loved them while in their care. To those of you that donated, we thank you from the bottom of our hearts we know that in this economy, it’s not easy to part with funds.

We have three that continue to struggle, one stronger than the rest. Please continue to keep them in your prayers, and if you feel moved to contribute towards their medical care, we would be forever grateful.

PayPal: [email protected]
Venmo:
Cash app: $ftarescue
Zelle: [email protected]

08/05/2024

Medical Genetics is an established field of human medicine however -these principles are not available to dog breeders, owners and lovers seeking to minimize the risk of disease in their dogs. Martine A. Gould MS, LCGC is a Licensed Certified Genetic Counselor with 32 years of experience in Human Genetics and over 20 years in dogs as a Breeder of Briards and Canine Genetic Testing facilitator. Martine is bringing you the principles of Clinical Medical Genetics to dog selection and breeding.

08/05/2024
07/21/2024

Cool article on one of the mechanisms of dominant negative effects on the wild type allele (explaining the variability seem in the presentation of dominant disease genes)

So I was going to do an article on this “from scratch” and specific to dogs but a colleague shared this on LinkedIn.  Th...
07/09/2024

So I was going to do an article on this “from scratch” and specific to dogs but a colleague shared this on LinkedIn. This is great and I now have this to reference. Will get my article done with dog specific examples and a couple other concepts like heterogeneity soon but meanwhile this is great and the principles are the same across species!

The same genetic variant found in different individuals can cause a range of diverse phenotypes, from no discernible clinical phenotype to severe disease, ev...

Great insights on calculated COI versus COI based on Genetic testing (real inbreeding). Purebred dogs do not need to be ...
07/06/2024

Great insights on calculated COI versus COI based on Genetic testing (real inbreeding). Purebred dogs do not need to be in**ed to produce quality dogs.

Adios to Pedigree research
Hello to DNA inbreeding testing

COI = coefficient of inbreeding.

DNA is now able to show us the actual COI of a dog. Historically we relied on pedigree research. We look 10-12 generations back and calculate what the COI prediction is for that dog. Often, we run this COI for a potential litter and get 3%-10% COI for many Golden Retrievers. From an ethical breeder mindset, those are nice low inbreeding numbers. We know all pure breeds are of course line-bred. That is why the dogs look and act like their respective breed. But we don’t want those 25% COI full sibling numbers! So for all of history, we have looked at pedigrees to decide what is safe.

Now DNA is proving our pedigree research is wrong!

DNA is showing a hundred years of line-breeding. And it also shows the truth of hidden inbreeding or outcrossing, meaning a pedigree can be false but the DNA tells the truth.

DNA testing companies to know your Golden Retriever’s COI are:
UC Davis
Embark
Laboklin

Learn more about the DNA Matchmaker Tool!

https://embarkvet.com/resources/matchmaker-for-breeders-an-easier-way-to-evaluate-potential-mates-2/

Juliet is NOT closely related on pedigree research to the dogs in red. It is due to European genetic Golden Retrievers being highly in**ed, from generations back.

Genetic Counseling is a well established field in human medicine. Genetic Counselors are Genetic Professionals specifica...
07/01/2024

Genetic Counseling is a well established field in human medicine. Genetic Counselors are Genetic Professionals specifically trained to gather and analyze family medical history and inheritance patterns to identify those at risk for genetic conditions. Based on an individuals' personal, medical and family history, Genetic Counselors will coordinate genetic testing and then explain the results and how to apply those results to manage genetic disease.

While you can access all types of genetic testing for dogs, there is very little access to expertise in the application of this information to reach your goals, just many strong and often emphatically stated opinions. Those who shout the loudest often know the least. It is a proven principle called the Dunning-Kruger effect that people will listen to those who speak first and loudest. This is something that the health of our dogs can no longer afford.

Genetic Counseling is informed expertise based on the sound application of well established and understood Genetic principles and genetic test results. The goal of Genetic Counseling is not to tell you what to do.

The goal of Genetic Counselor is:
provide you with an accurate analysis and explanation of the genetic information
give you a format to help you clearly understand genetic information
help you process the implications of genetic information for the health of current, past and future generations
discuss the potential options forward with the potential outcomes/ ramifications of those various options.
Provide you the understanding and tools to make a plan forward consistent with your goals and what you value.
Put simply, Genetic Counseling is to give you informed choices to benefit you, your animals and the next generation.

Genes and Genetic principles are the same across species Dogs were the first domesticated species and have evolved by our side for millennia. We suffer from many of the same diseases. There are many examples of dogs being a model for gene discovery and treatment of human disease. In fact the first Gene Therapy EVER developed is based on the natural occurring animal model for the RPE65 gene in my breed, Briards!. Called Leber Congenital Optic Neuropathy in Humans and Congenital Stationary Night Blindness in Briards--an early onset form of Retinitis Pigmentosa. Studies done on Briards resulted in the first successful gene therapy in animals and the first to be clinically offered to humans. Restoring vision to those who were once blind.

As an experienced Genetic Counselor, Diagnostic Genetic Testing Specialist and Breeder --I am uniquely equipped to assist you in a better understanding of managing genetic disease. Realize that in human medicine --we work as a multidisciplinary team. Most veterinarians like most human physicians have relatively little training in managing genetic disease. In dogs, people have long thought that the "right thing to do" regarding managing disease in dogs was intuitive --eliminate all affected dogs and there relatives from breeding. This reflects a fundamental lack of understanding of the inevitability of genetic disease. Genetics is just not that straight forward or simple.

You would not ask an Orthopedic surgeon to examine your dog's eyes. Why would expect that someone with no specific training in Genetics or experience in breeding would be the best resource regarding the management of genetic disease. We have to "vet" our genetic experts and reject those who's expertise is not what the claim it to be. Story here!!!

Many in the dog world will proport the use of population genetics and animal husbandry techniques for dog breed management. Rule number 1 of population genetics--you do not breed populations--you breed individuals. Population genetics is great for looking up data in a book but of limited value in specific breed choices or disease management in breeding. Based on population genetic I know 1 in every 25 Caucasians carry a gene for cystic fibrosis and 1in every 10 African Americans has a gene for Sickle Cell Anemia but the patient in front of me either has the gene and might pass it on to their children or they don't.

In livestock we do not care generally care about the long term health of a specific animal and the longevity of that animal. You are select animals based on what they produce. Would there be reason to notice or be concerned about an incontinent cow, a blind cow or a cow intolerant to exercise? Estimated breeding values require a great deal of data and advanced computation. Not practically accessible to the everyday dog breeder.

In human medicine we observe and analyze what happens in individuals and families much like we do in dogs, I can easily say and breeders can observe--- "what does or did the dog PRODUCE". When there is a recessive condition in the breed---in the absence of a genetic test, you know the dog is at risk for the gene based on its line, breed or pedigree. When the dog produces an affected puppy--that is when you KNOW they have the gene.

Doctors diagnose disease. Genetic Counselors construct the medical genetic pedigree, coordinate the genetic testing, and explain the results and their implication. This has been a missing piece in the dog world and I am excited to bring this expertise to you for your and for my love of dogs.

With a focus on personalized care, my services are designed to empower you with the knowledge and tools needed to make informed decisions for your canine companions. Whether you're seeking Genetic Counseling, Education, research facilitation, or DNA collection coordination: DogGenes is here to provide comprehensive education and professional Genetic services.
Committed to Canine Health and Wellbeing, my goal is to equip you with sound genetic principles and the most accurate and up to date information available for you to reach the goals of the best health and well being for your dogs.

Canine Genetic Counseling, Education, and Professional Services, I strive to ensure that you receive the best information for the highest quality care for your dogs. I look forward to learning your experiences and to helping you achieve your goals for your dogs. your breed towards a healthier future for all.

Genetic Counseling is a well established field in human medicine. Genetic Counselors are Genetic Professionals specifically trained to gather and analyze family medical history and inheritance patterns to identify those at risk for genetic condition

06/28/2024

Amazing group for research participation. Check it out and see if your dogs can help!!

https://www.facebook.com/SVMgenetics?mibextid=LQQJ4d

We are a team of veterinarians and scientists working to advance the understanding of the genetics and progression of companion animal diseases.

We are always recruiting new participants for our studies. Inquiries please email [email protected]

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2110 Upper Branch Cove
Cove, TX
78620

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